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Objectives: Primary spinal melanoma (PSM) of extramedullary origin is a rare malignant condition with limited current literature in regards to its clinical course, magnetic resonance imaging (MRI) findings, treatment strategies and prognosis

It has been proposed that a reduced GST activity in these individuals would slow the rate of excretion of isothiocyanates, thereby increasing tissue exposure to isothiocyanates after cruciferous vegetable consumption (55)

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In mice models, GPX4-a critical antioxidant enzyme of ferroptosis, deletion has been shown to exacerbate myocardial hypertrophy induced by a high-fat and high-sugar diet, primarily due to increased mitochondrial lipid peroxidation [219]

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