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According to the study, these multifunctional double selenide nanosphere NPs effectively restored GPX1/4 expression levels, enhanced the antioxidant capacity of brain tissue, diminished neuronal damage and neurofibrillary tangles, prevented neuronal ferroptosis, and ultimately ameliorated cognitive deficits in APP/PS1 mice

To view a copy of this licence, visit About this article Cite this article Kumari, P., Sullivan, L.M., Li, Z

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Those lighter melanins can participate in the clinical efficacy of those compounds, but the well-demonstrated deleterious effects of pheomelanin raise concerns about the long-term safety of these approaches [16]

To confirm the potential functions of the 13 putative GhGPXs, we analysed the homology between GhGPX and AtGPX protein sequences using WU-BLAST2 ( Using the protein sequences of GhGPXs, we found the highest homology of AtGPX to each GhGPX protein (Table 2), for example, the amino acid sequences of GhGPX1 and AtGPX1 had 79% identity, while GhGPX6 and AtGPX6 had 78% identity