FIGURE 4 4.3 Mechanisms and consequences of mitochondrial ROS imbalance following rotator cuff injury Mitochondria are the primary source of reactive oxygen species (ROS) in skeletal muscle, and oxidative stress is significantly exacerbated after rotator cuff injury (Thankam et al., 2018)
This quantitative understanding is now driving the development of pathway-specific inhibitors, such as PKC- selective antagonists, SGLT2 inhibitors, and glyoxalase-1, which have shown promise in preclinical models for breaking this cycle without globally suppressing physiologically important ROS signaling -Figure 3 (Oliveira et al., 2023
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