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However, this differs fundamentally from targeted fibromyalgia therapies like pregabalin or duloxetine, which address pain pathways more directly

Reduces Pore Size: Niacinamide clears out clogged and infected pores and helps shrink their size, making them less visible

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Furthermore, the absence of mNSS results poses significant limitations

To the best of our knowledge, this study represents the first meta-analysis specifically designed to systematically evaluate the clinical effects of GLP-1RAs on AUD and alcohol-related hospitalization

However, ethical considerations, external validity limitations, challenges in double-blinding, and interference from internal and external factors, coupled with inadequate statistical power and significant financial/temporal requirements, have hampered the feasibility of conducting RCTs