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11 Related Stories Weight loss drugs may reduce binge eating disorder symptoms Lactoferrin yogurt helps preserve iron stores in women with gestational diabetes Semaglutide dose may matter more than weight loss for heart health The cardiovascular benefits of semaglutide are attributed to several mechanisms beyond weight loss

IGF-IR inhibitor sensitizes PIK3CA-mutant breast cancer to PI3K inhibitors [123]

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Interestingly, the treatment demonstrated dose-dependent therapeutic effects, with moderate dosages proving more effective than high doses (1,000 mg/kg), possibly due to pharmacodynamic principles, where excessive concentrations saturate biological pathways and diminish therapeutic outcomes (Tyagi et al., 2025

Circulation 109(5):607612

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