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Intracellularly, labelling patterns showed a decrease in the proportion of glucose-derived carbon in TCA cycle metabolites in the treated samples compared to controls
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RNA sequencing analysis demonstrated extensive transcriptional reprogramming in cold-acclimated T cells, characterized by the upregulation of pathways related to ribosome biogenesis, RNA processing, transcriptional regulation, and protein quality control, accompanied by the downregulation of gene sets involved in DNA replication, DNA repair, and cell cycle progression
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Tomaz, S., Wang, D., Zabalegui, N., et al
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