As the authors reported: Our findings demonstrate that all three GLP-1 analogs exhibit significant anti-obesity effects in MC4R KO mice. Significant weight and metabolic improvements Weight reduction occurred across all treatment groups: Semaglutide reduced body weight by an average of 19.7 percent Retatrutide achieved a 24.1 percent reduction Tirzepatide , which targets both GLP-1 and GIP receptors, produced the largest effect with a 31.6 percent reduction Importantly, these outcomes occurred in animals completely lacking MC4R function
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To minimize subjective bias, all series of the same type of meal in both phases were randomly assigned to different trial days
For reference, the UK Summaries of Product Characteristics (SmPCs) for semaglutide (Wegovy) and tirzepatide (Mounjaro) both list injection site reactions including erythema, pruritus, and bruising as recognised adverse effects of their respective drug classes
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