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doi: 10.1016/S0040-4020(01)90096-1

Pathogenesis of adenomyosis: an update on molecular mechanisms

This issue is a particular concern with the in vitro studies reporting an anti-proliferative effect of metformin and promoting its use as an adjunct for the treatment of various cancers as, in most of these studies, the concentration/dose of metformin that have been used would most likely prove toxic in patients