Naunyn-Schm Arc Pharmacol
Add The New York Post on Google GLP-1 meds could be stifling your senses
If not, the Mann-Whitney test was used
At a glance Drug / isotretinoin (Accutane), oral retinoid for severe nodular acne Supplement / green tea extract (GTE), standardized to EGCG (epigallocatechin gallate) Primary concern / additive hepatotoxicity at GTE doses 400 mg EGCG/day Secondary concern / CYP1A2 and CYP3A4 modulation may shift isotretinoin metabolism Dietary green tea risk / low, typical brewed cup contains 50 to 100 mg EGCG Monitoring required / LFTs (ALT, AST) at baseline and weeks 4, 8 per iPLEDGE protocol FDA DILI signal / GTE linked to drug-induced liver injury in 29 case reports reviewed by NIH LiverTox Recommendation / avoid concentrated GTE supplements during isotretinoin
Overdosing or underdosing can lead to severe health issues, including hypoglycemia, gastrointestinal problems, and ineffective weight loss results
Excessive iron ions can induce membrane lipid peroxidation via Fenton reaction and cell damage
