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Depletion of endogenous GSH sensitizes cells to cuproptosis, whereas GSH supplementation mitigates copper-induced proteotoxic stress 164,168

The Control formulation (i.e., HA-only) includes Sequence 1 (i.e., HA-first) during V1V3 and Sequence 2 (i.e., GSH-C4-first) during V4V6

FIRDAPSE is a prescription medicine used to treat Lambert-Eaton myasthenic syndrome (LEMS) in people 6 years of age or older

Tesamirelin is a bit more long lasting than Sirmirelin, and therefore is taken typically about three times per week, not five times per week

Weeks three and four: peak purging Purging often intensifies before it resolves

Imaging was performed on an EVOS Digital Inverted Fluorescence Microscope (Invitrogen), using the FITC (green) and the DAPI (blue) filters