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Mice were euthanized on days 27 and 28 of the study

Specifically, metformin attenuates neointimal hyperplasia by inhibiting smooth muscle cell proliferation and migration through the insulin-signaling pathway by inhibiting the expression of advanced glycation end product (AGEs) receptors, which are related to cancer mortality through AMPK [21,22]

Pediatric pharmacokinetics and long-term safety require clarification, particularly for polyphenols and carotenoids with intrinsically low oral bioavailability and potential interactions with conventional medications like antipsychotics or stimulants (Mousavinejad et al., 2018)

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Provides antioxidant protection against skin ageing