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Parisi R, Symmons DP, Griffiths CE, et al

A survey of changing trends in modelling radiation lung injury in mice: Bringing out the good, the bad, and the uncertain

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reported that there is a ferroptosis system in mitochondria mainly composed of dihydrolactate dehydrogenase, which also induces lipid peroxidation in the mitochondrial membrane by promoting the reduction of CoQ10 to combat ferroptosis (81)

Intrinsic DILI happens in predictable patterns, such as taking over 7.5g of acetaminophen (APAP) in one dose, which can cause liver damage

These compounds work individually and together through several mechanisms of action, including stimulating the bodys metabolic master switch AMP-activated protein kinase (AMPK), an enzyme that acts to burn stored fat and inhibit the creation of new fat cells