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Hydroxocobalamin is naturally created in the digestive tract by bacteria when food is being broken down and contributes to the creation of DNA

Clinical evidence remains limited

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[107] One theory is that consumption of large amounts of folic acid leads to detectable amounts of unmetabolized folic acid circulating in blood because the enzyme dihydrofolate reductase that converts folic acid to the biologically active forms is rate limiting

10.1016/j.biopha.2016.12.109 90 ShakerF