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Primer pairs oriTF/oriTR, gr IF/ gr IR, and gr OF/ gr OR were used to confirm the deletion of gr

Hurst et al., 1998)

Approximately 20% of CRC patients will develop metastases, resulting in a less than 5-year survival rate of only 14% with conventional treatment (Rumpold et al., 2020)

Recent studies suggest that other cell populations in the tumor microenvironment, including immune cells and cancer-associated fibroblasts, depend on iron and can contribute to iron dysregulation in tumors

Therefore, we investigated whether the disruption of D2R-DAT can exert any beneficial effects on the ADHD-like symptoms (i.e

LEfSe analysis revealed taxonomic shifts characterized by enrichment of Actinomycetaceae , Streptococcaceae (genus Streptococcus ), Rothia , and Dialister , alongside depletion of beneficial taxa such as Lactobacillus