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Regulatory bodies such as the FDA and EMA must continue to monitor and address the risks of counterfeit and compounded GLP-1 agonists to protect public safety

A randomized, placebo-controlled pilot study examined adding phentermine to liraglutide (a GLP-1 agonist similar in class to tirzepatide) in adults with obesity who had already been on liraglutide for one year and achieved approximately 12% weight loss

The realistic caveat is that long-term maintenance without pharmacologic or procedural support is difficult for most people which is the entire reason the rest of this list exists

The filing comes as the diabetes market is being reshaped by blockbuster GLP-1 drugs from companies such as Novo Nordisk A/S and Eli Lilly and Co., raising the question of how new oral therapies can differentiate themselves in an increasingly crowded field

2020;192:E875E891

2 capsules three times daily) in mild-to-moderate heart failure