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Unlike existing weight loss medications that target one or two hormone receptors, Retatrutide activates three distinct pathways simultaneously

Standardization of protocols, patient stratification, and integration with disease-modifying therapies will be critical for translation into clinical practice

Friedman JM, Polifka JE

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The Cell Ranger pipeline (10x Genomics version 3.1.0) was used to perform sample demultiplexing and to generate FASTQ files for read 1, read 2, and the i7 sample index for the gene expression and cell surface protein libraries

Estrogens can act as pro-oxidant or anti-oxidant agents depending on cell types and ratio of different types of estrogen receptors