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3.3.2 Arthroscopy Arthroscopic debridement and lavage were historically used in the management of knee OA, especially in the presence of mechanical symptoms such as locking or catching (Medical Advisory Secretariat, 2005)

By reducing tyrosinase activity, it shifts production from eumelanin (darker pigment) to pheomelanin (lighter pigment), resulting in a gradual lightening effect

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doi: 10.1016/j.mam.2004.02.013