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HA injections reported that PRP patients had better pain relief and functional improvement at 6 and 12 months post-treatment , whereas HA benefits diminished after 6 months (PMID: 30212925)

doi: 10.1158/2159-8290.CD-21-0900 88

Unfortunately, it is also noted in highly metastatic tumors, where it is unclear if it is playing a suppressive or stimulatory role

p16 is crucial for maintaining senescence by regulating Rb protein phosphorylation to inhibit cell division 9