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Evidence-based levers that reliably move the needle: A sustainable calorie deficit with adequate protein Resistance training plus daily movement Sleep and stress management (often underestimated) Clinician-guided options when appropriate, including FDA-approved obesity medications (e.g., Wegovy and Zepbound ) and weight loss injections A good rule of thumb: don't outsource a fundamentals problem to an unproven tool

Reported side effects included: Nausea (most common, particularly during dose escalation) Vomiting Diarrhea Constipation Decreased appetite (this is also the mechanism, so it is both a side effect and the goal) Discontinuation due to side effects in the Phase 2 trial was around 16% in the highest dose group

FIGURE 4 3.3.4 The comparison of TCM syndrome scores between two groups Statistical results showed that mean SD of TCM syndrome scores respectively were 34.2 12.0, 28.7 10.1 in RG group and RG + CHF group after treatment

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Most active individuals need 1.62.2g protein per kg body weight daily