In addition to acting as the major intracellular activator of artemisinins, ferrous heme is the primary source of oxidative stress during the blood stage of P
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10.1016/s0006-291x(02)02397-2395 Biochem
Key residues 38 YGSL 41 , D 68 , R 72 , E 115 and Y 143 are responsible for high affinity substrate binding via salt bridge interaction with the glutamate (E 115 ), hydrogen bonding as well as a cation -interaction involving Y 143
For reproductive toxicity evaluation, Sprague Dawley rats (26 males and 26 females) received doses at 60, 180, or 540 mg/kg every 28 days (males on days 1, 29, and 57
Single-cell RNA-sequencing identifies disease-associated oligodendrocytes in male APP NL-G-F and 5XFAD mice
