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The clinical evidence overwhelmingly favors semaglutide for meaningful fat reduction, but the nearly nonexistent side effect profile of AOD 9604 gives it a unique position for specific use cases

The crossover trial by Tempesta et al 21 was evaluated using the RoB 2 crossover tool, and judgments were consistent with other RCTs, showing some concerns in the randomization and measurement domains

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Thus, evidence- based behavior change programs like Omada are ideally positioned to support individuals actively using GLP-1s through their weight loss journey

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