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The COMBO-DN study - a multinational, randomized, double-blind, parallel-group study in patients with diabetic peripheral neuropathic pain
Intravenous B12 Administration For those with severe vitamin B12 deficiency, getting B12 through an IV is a quick and effective way to treat it
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the appetite-suppressing effects of GLP-1 agonists require careful consideration Medication absorption : Delayed gastric emptying may theoretically affect the absorption of oral Crohn's disease medications, though clinical significance remains unclear Ongoing monitoring strategies include: Symptom diary : Patients should maintain records distinguishing new gastrointestinal symptoms from their baseline Crohn's pattern Faecal calprotectin testing : When clinically indicated to differentiate inflammatory activity from functional symptoms, in line with NICE DG11 guidance Nutritional surveillance : Regular assessment of weight, body composition, and nutritional markers (albumin, vitamins, minerals) Dose titration : Slower than standard dose escalation may improve gastrointestinal tolerability Collaborative care between gastroenterology and diabetes/obesity services is strongly recommended
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