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Why It Matters Clinical trials are supposed to determine if medications are safe and effective

Mendelian randomization: using genes as instruments for making causal inferences in epidemiology

Its high intracellular concentration (typically ranging from 1 to 10 mM) and the reactive thiol group of its cysteine residue make it a highly effective antioxidant

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Moreover, additional roles for GLP-1 have been revealed since the discovery of an extrapancreatic distribution of GLP-1 receptors in multiple organs such as the gastrointestinal tract, lung, heart, liver, and kidneys [58910], and evidence shows that administration of GLP-1 or GLP-1 RAs result in beneficial effects in these organs, indeed [11]