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3.3 Immune system enhancement The natural substances can act as immune checkpoint and co-inhibitory modulators, some polyphenols decrease the expression of tissue-and tumoural PD-L1 or of CTLA-4 on T cells giving a mechanistic reasoning to combination with nutritional support in patients treated with check point inhibitors, eventually reversing acquired resistance to treatment or decreasing the effective dose for drug administration (193)
doi:10.3390/pharmaceutics17081036 Rosenstock J, Hsia S, Nevarez Ruiz L, et al
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Children with ADHD are less likely than their peers to meet recommended levels of physical activity
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