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[76] The presence of such metals in biological systems in an uncomplexed form (not in a protein or other protective metal complex) can significantly increase the level of oxidative stress

Enhanced Intestinal Permeability and Its Link to Autoimmune Disease Enhanced intestinal permeability (EIP), often called "leaky gut," has been implicated in the pathogenesis of various autoimmune diseases

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It presents with a broad clinical spectrum, ranging from asymptomatic or non-specific symptoms, such as fatigue or lightheadedness, to severe manifestations, including nausea, vomiting, alteration of consciousness, and even coma, which can be life-threatening 3,4