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The disulfide moieties not only enhanced mucoadhesion but also increased TJ opening via protein tyrosine phosphatase inhibition, reducing occludin dephosphorylation

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At 68 weeks in the phase 3 trial, 23.7%

Measurement of reactive oxygen species (ROS) Lucigenin-enhanced chemiluminescence was used to detect NADPH-dependent ROS generation in hMEC, hLEC, hAEC and hPEC as we previously described 43