GLP-1 medications can also cause tiredness, especially when treatment starts or doses increase, because of reduced calorie intake, dehydration, gastrointestinal side effects, and changes in glucose levels
2 Mechanistic insights into metformins glucose-lowering actions Metformin exerts pleiotropic metabolic effects extending beyond glucose control, notably regulating energy metabolism, autophagy, and redox balance
Freeman LR, Keller JN (2012) Oxidative stress and cerebral endothelial cells: regulation of the bloodbrain-barrier and antioxidant based interventions
Vegetarians may have trouble getting enough vitamin B12 because this nutrient is primarily found in meat
doi: 10.1016/j.mehy.2020.110102 37 Cerqueira BorgesR.Sayuri HohmannM.MarquesB
That roughly 8:1 potency ratio means the GLP-1 activity dominates, which helps explain why the drug lowers blood sugar rather than raising it despite the glucagon activation