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Importantly, these effects of DHA were specific for DHA and were not be detected when DHA was replaced by arachidonic acid, another highly abundant polyunsaturated fatty acid in nerve cells, under identical experimental conditions (Casaas-Snchez et al., Absolute quantification of Gpx4 isoform expression in unstimulated HT22 cells revealed that the largest expression values corresponded to the cytoplasmic variant and the lowest for the nuclear mRNA variant, with a difference of about 3 orders of magnitude (Figure 2)

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