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They also act on appetite centres in the brain, reducing hunger and food intake, which explains their effectiveness in weight management

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For example, a person taking semaglutide alone might lose a certain amount of weight, but when combined with lipotropic injections, the weight loss can be significantly higher

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Similarly, as seen in non-syndromic obesity (43, 44), semaglutide treatment discontinuation, which occurred in Patient 1 and Patient 2, resulted in weight regain