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Yuan, C., et al
Internal pilot work before committing to larger dual-peptide or triple-pathway strategies
The study only employed a single drug dose, overlooking dose-dependent investigations, which will also be addressed in subsequent research
Fortunately, a meta-analysis of SGLT2i CVOTs found that diabetic ketoacidosis was rare, occurring in 0.1 to 2.2 per 1,000 person-years in those treated with a SGLT2i, albeit with a significantly greater risk compared to placebo (HR, 2.46
doi: 10.3390/nu15184072
And so for most people, I think they probably use higher dose than a lot of these supplements actually have
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