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When BMI is between 27-30 the individual must have 1 other weight related medical condition such as: type 2 diabetes, hypertension, high cholesterol, or sleep apnea

GLP-1s weight loss mechanisms include powerful appetite suppression through central nervous system effects, delayed gastric emptying reducing meal size and frequency, alterations in food preferences (reduced preference for high-fat, high-sugar foods), increased satiety and reduced hunger between meals, and possible modest increases in energy expenditure

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10.1007/s11906-020-01111-8 318

The results also show that temperature has been demonstrated to substantially influence solubility