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2.3 Glutamate modulators 2.3.1 Riluzole Glutamate excess can induce CNS neurotoxicity, leading to interest in developing a class of drugs which modulate glutamate activity directly or indirectly (Grados et al., 2015)

2.2.6 Golgi apparatus: regulatory mechanisms in ferroptosis The Golgi apparatus is a vital organelle involved in the post-translational modification, sorting, and trafficking of proteins and lipids within the cell (81)

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Arguably the most powerful antioxidant in the body, its mechanisms are many, including metabolism of toxins, immune system function, prevention of oxidative cell damage, and protection from carcinogens and chemotherapies

Chromium has an insulinotropic impact inhibiting epinephrine, which could be related to the decrease in oxidative stress biomarkers