IFD foci depend on MTs and dynein motors for formation Under high proteostress conditions, ubiquitinated and non-ubiquitinated aggregated proteins in mammalian (and other) cells can be linked to adaptors such as HDA-6/HDAC6, SQST-1/p62, and the HSP-1/Hsc70/BAG3/FTT-2/14-3-3 complex, which connect to dynein motors and move along microtubule tracks to juxtanuclear sites to deposit aggregate cargos 26,27,28 (summary diagram in Fig
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Trends in Biochemical Sciences, 45 (6), 545546
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albicans was performed for each primer in triplicates Reporting summary Further information on research design is available in the Nature Research Reporting Summary linked to this article