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In 2024, it also gained FDA approval for a second use: reducing the risk of serious heart problems, such as heart attack and stroke, in adults with cardiovascular disease and obesity or overweight, and in 2025 gained approval for helping treat MASH
Biomedicines 12:355 Chatree S, Thongmaen N, Tantivejkul K, Sitticharoon C, Vucenik I (2020) Role of inositols and inositol phosphates in energy metabolism
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Because of their effectiveness in treating obesity and diabetes, the WHO added GLP-1 therapies to its Essential Medicines List for managing type 2 diabetes in high-risk groups in September last year
However, although leptin supplementation is effective for patients with congenital leptin deficiency, leptin has little effect on weight reduction
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