Sun exposure (especially when intense and intermittent, eg, while on vacation) is the primary environmental influence (eTable 361.1 )
[DOI] [PubMed] [Google Scholar] 113.Madhavi D., Kagan D., Seshadri S
Oncotarget 8 , 7854578555 (2017)
However, it does not follow the ABCDE of melanoma rule
Approaches include redox interactions with high-valent metal ions (like Cu 2 and Fe 3 ), suppression of GSH synthesis using agents such as BSO, the use of nanozymes that mimic enzymatic activity, and direct GSH neutralization through molecular binding [18]
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