[DOI] [PubMed] [Google Scholar] 60.Horvath VJ, Vittal H, Ordog T
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Always check for signs of contamination and store it properly to maintain its quality
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To date, incretin-based approaches for obesity management appear as the most promising and rapidly developing (Supplementary Table 1), with innovations such as once-weekly (OW) injectable triple GIPR/GCGR/GLP-1R agonist retatrutide (LY3437943), cagrilintide (long-acting amylin analogue)/semaglutide 2.4 mg (CagriSema) combination, GCGR/GLP-1R dual agonists, high-dose oral semaglutide, and oral non-peptide GLP-1 receptor agonist orforglipron, with relevant implications in terms of patients compliance and environmental sustainability
However, some patients do report acid reflux or heartburn during treatment, particularly when gastric emptying is significantly slowed or during rapid weight loss phases