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Probenecid and cimetidine, which block active tubular secretion by targeting organic anion transporter (OAT)1 and 3, tend to have a greater impact in men, suggesting that male renal tubules have higher baseline transporter activity (Schwartz 2003

Patients using insulin or insulin secretagogues (such as sulfonylureas) face increased hypoglycemia risk with tirzepatide dose increases

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This contextual variability may influence the generalizability of our findings

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The article stresses that cost savings must not override medical safety or proper clinical oversight