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It has a smaller molecular size, which makes it easier for it to penetrate the dermis and have a more pronounced effect at the cellular level
Combined rehabilitation with alpha lipoic acid, acetyl-L-carnitine, resveratrol, and cholecalciferolin discogenic sciatica in young people: a randomized clinical trial
Reproductive Biology and Endocrinology, 7 , 120
So while you may lose weight due to better gut health with probiotics or prebiotics, that weight loss wont be as drastic or immediate as it may be with a GLP-1 prescription drug
J Pediatr Surg 39(7):10031013
Oral supplements are good for those who cant or dont want to get shots
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