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Description

The deletion of ATF4, an upstream factor of ChaC1, in embryonic fibroblasts, results in a ferric oxide-dependent death phenotype, emphasizing the role of ATF4 as a downstream molecule of the eIF2/ATF4 pathway (117)

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5-Amino-1MQ's mechanism centers on NNMT inhibition: NNMT inhibition : Selectively blocks NNMT with an IC50 of approximately 1.2 microM

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