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Some in vitro data also suggest a degree of direct adrenal receptor engagement independent of pituitary ACTH release

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Our findings were based on 113 RCTs, including 14 887 participants, and indicated that stimulants were the only intervention that was supported by evidence of efficacy in the short term (ie, at timepoints closest to 12 weeks) for core symptoms of ADHD in adults (both self-reported and clinician-reported) and was associated with good acceptability (all-cause discontinuation)

Periorbital puffiness, the slight swelling around the eyes that accompanies inflammation and excess weight, resolves as systemic inflammation decreases

3 (download XLSX Statistical source data Source Data Extended Data Fig

Licensed-provider evaluation Every patient completes an evaluation before any prescription is written