Poels K, Schnitzler JG, Waissi F, Levels JHM, Stroes ESG, Daemen MJAP, et al
Not blind optimism, but confidence in our ability to respond, adapt, and choose again
Cardiovascular and other Dhondt et al
In response to different extracellular stimuli, the complex may dissociate and JNK can phosphorylate c-Jun, a component of the activator protein-1 transcription factor
17,22, This provides a rationale for using GLP-1 together with GIP agonism, as GLP-1 may lower glucose sufficiently to unmask the incretin effect of GIP, while GLP-1 action may overcome the potentiating effect of GIP on GCG secretion
These pharmacological agents demonstrate efficacy by simultaneously targeting multiple metabolic pathways