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While traditional synthetic nanomaterials demonstrate strong therapeutic efficacy, their persistence and toxicity raise significant environmental concerns

No claims are made regarding therapeutic application, clinical relevance, physiological outcomes, or suitability for human or veterinary use

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Compensatory Insulin Receptor (IR) Activation on Inhibition of Insulin-like Growth Factor-1 Receptor (IGF-1R): Rationale for Cotargeting IGF-1R and IR in Cancer