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In this context, the aim of the present document is to summarize, in the form of a narrative literature review, the currently available data on the main mechanisms of action of GIP/GLP-1 co-agonists and the clinical effects of tirzepatide evaluated in various clinical trials

Together, these three compounds span the selectivity spectrum from non-selective (MT-2) to MC4R-optimized (PT-141) to MC1R-selective (MT-1)

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