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Here, we used PURE G4 partially functionalized with lactate molecules (LA) at the surface, a conjugation strategy to direct these nanoparticles to MCT1 expression related to increased glycolysis and complexed with anti- GLS1 small interference RNAs (anti- GLS1 -siRNAs) to target glutamine metabolism in GBM cells
Some patients benefit from genetic testing that reveals predispositions in peptide pathwaysthis information can be interpreted alongside clinical criteria to refine personalization strategies and safety planning
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