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Gastrointest Cancer Res 2010;(Suppl 1):S1623
A study of 39 patients suggested that intake of DAO produced a statistically significant reduction in symptoms associated with exogenous histamine ingestion, although single symptoms were not found to be reproducible.[11] Ultimately, diminished serum DAO levels appear to be associated with changes in histamine degradation and serum histamine levels.[10] Although the mechanism of histamine degradation is uniform throughout the body, Histagest-DAO only addresses excess exogenous histamine found in the folds, villi, and microvilli of the small intestine