Efficacy and safety of the combination or monotherapy with GLP-1 receptor agonists and SGLT-2 inhibitors in type 2 diabetes mellitus: an update systematic review and meta-analysis
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The fundamental distinction lies in their mechanism: sulfonylureas provide continuous insulin stimulation (carrying intrinsic hypoglycaemia risk), whilst incretin mimetics offer glucose-responsive action with additional metabolic benefits beyond glycaemic control
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