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154 The release of IL-1 amplifies the inflammatory cascade by promoting cytokine production, particularly by inducing IL-6 expression in monocytes and macrophages, thereby sustaining inflammation

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Mejora la energa, el estado de nimo y la funcin cognitiva : Al modular la sealizacin de la GH y el IGF-1, se ha observado que esta combinacin mejora la claridad mental, la concentracin y el bienestar general

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A few mechanisms that don't reduce neatly to mesolimbic dopamine: (1) conditioned aversion, GLP-1 activation engages nausea/malaise circuits, so some of the reduction in substance use may reflect aversive conditioning rather than reward modulation per se