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In the SUSTAIN 6 trial (published in the New England Journal of Medicine, 2016), which examined cardiovascular outcomes in over 3,000 patients with type 2 diabetes at high cardiovascular risk, participants receiving semaglutide demonstrated statistically significant reductions in major adverse cardiovascular events

And, like most medications, semaglutide is not a cure

Contraindications listed elsewhere include personal or family history of medullary thyroid cancer and multiple endocrine neoplasia syndrome type 2, with monitoring needed in chronic kidney disease

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Rarely, an injection causes an allergic reaction

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