2020;383:1413-1424 Anker SD, et al
For injectable semaglutide, one small human study didnt detect the medication in breast milk, although levels may have been too low to be detected by the testing tools used
"By their nature, compounded drugs are supposed to be temporary to fill a gap in the market
In the PIONEER clinical trial programme, which included over 9,500 participants, Rybelsus achieved HbA1c reductions of approximately 0.91.4% from baseline, depending on the dose and comparator used
Both patients and doctors need to understand that these drugs also lower cardiovascular disease outcomes that may be even more important than their weight loss effects since cardiovascular disease is the leading cause of death for persons with diabetes or overweight/obesity (evidence already published for Ozempic showing reduction in cardiovascular events, pending for Wegovy and clinical trials are ongoing for Mounjaro). Type 2 diabetes can be managed
But pregnancy represents a situation where this particular tool needs to be set aside, even though the underlying condition (obesity) would benefit from continued treatment
