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This is associated with reduced capacity to utilize fatty acids and glucose, and this impairment promotes lipid accumulation within muscle, aggravating IR and muscle dysfunction

The profile of the REVEAL-1 Cohort closely mirrors that of the REMAIN-1 Midpoint and Pivotal Cohorts, with an average age of 50 and a gender distribution of 86% women

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The New England Journal of Medicine , 375(19), 1834-1844

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Several mechanisms have been described through which eCO 2 levels can improve WUE and, consequently, crop yield